Optimizatin of fed-batch processes: Challenges and solutions

Optimal Adaptive Control of Fed-batch Fermentation Processes

This paper presents a unifying methodology for optimization of biotechnological processes, namely optimal adaptive control, which combines the advantages of both the optimal control and the adaptive control approaches. As an example, the design of a substrate feeding rate controller for a class of biotechnologlcal processes in stirred tank reactors characterized by a decoupling between biomass ...

The scale-up of microbial batch and fed-batch fermentation processes.

A STUDY ON CLAVULANIC ACID PRODUCTION BY Streptomyces clavuligerus IN BATCH, FED-BATCH AND CONTINUOUS PROCESSES

Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasi...

Intelligent Software Sensors for Fed-Batch Fermentation Processes

Software sensors have attracted great research interests due to the problem of lacking suitable and robust online sensors for key fermentation variables in fed-batch fermentation processes. In this paper, intelligent software sensors have been developed based on multivariate statistical process control methods. The software sensors not only provide real time estimation of key variables but also...

Evolutionary Algorithms for Optimal Control in Fed-Batch Fermentation Processes

In this work, Evolutionary Algorithms (EAs) are used to achieve optimal feedforward control in a recombinant bacterial fed-batch fermentation process, that aims at producing a bio-pharmaceutical product. Three different aspects are the target of the optimization procedure: the feeding trajectory (the amount of substrate introduced in a bioreactor per time unit), the duration of the fermentation...